Chichibabin (2)

Synthesis of substituted pyridines by thermal cyclocondensation of aldehydes and ammonia.

The reaction takes place with aliphatic and aromatic ketones, alpha,beta-unsaturated aldehydes and keto acids.

Also see Hantzsch

Bibliography

• Chichibabin A. E., ZhRFHO, 1906, 37, 1229; J. prakt. Chem., 1924, 107, 122.
• Lomakin A. N., ZhOH, 33, 204.
• Chumakov Y. I., Piridinovnye osnovaniya, Kiev, Tehnika, 1965, 8.
• Kametani T., Nemoto H., Takano S., Chem. Pharm. Bull., 1968, 16, 367.
• Elderfield,1, 352; 6, 214; 7, 161.