Leuchs

Synthesis of oxazole-2,5-didiones from alpha-amino acids and aryl or alkyl chloroformates in the presence of sodium carbonate and thionyl chloride.

Cyclization can be achieved by heating in vacuum.

Also see Fuchs.

Bibliography

• Leuchs H., Ber., 1906, 39, 857.
• Woodward R. B., Schramm C. H., J. Am. Chem. Soc., 1947, 69, 1551.
• Farthing A. C., J. Chem. Soc., 1950, 3213.
• Petri E. M., Staverman A. J., Rec. Trav. Chim., 1952, 71, 385.
• Bartlett P., Jones R. H., J. Am. Chem. Soc., 1957, 79, 2153.